Endocrine Abstracts

We report two cases of severe hypocalcaemia developed after intravenous administration of pamidronate in patients with severe hypercalcaemia secondary to multiple myeloma. Both of them develop symptomatic hypocalcaemia few days after treatment. Both patients was probably vitamin D deficient (both serum 25-hydroxyvitamin D level was low less than 15 (NR 25–120 nmol/l) because of a combination of poor oral intake, inadequate sunlight exposure, and the development of renal f...

We present the case of a 50-year-old woman who presented with 12 months of amenorrhea associated with signs of virilisation. Investigations revealed markedly raised serum concentrations of testosterone (9 nmol/l), whereas sex hormone binding globulin, random cortisol, androstenedione, 17-hydroxyprogesterone and dehydroepiandrosterone sulphate concentrations were all within the normal range. Computed tomography scan of the pelvis and abdomen showed a slightly bulky right ovary,...

Background: Resistance to thyroid hormone (RTH) is a rare autosomal dominant condition of altered tissue responsiveness to thyroid hormone (TH) characterised by elevated serum FT4 and FT3 and non-suppressed TSH levels caused by mutation in the thyroid receptor (TR) β gene. Different isoforms of TR are expressed in the heart and regulate genes that encode structural and regulatory proteins. The syndrome is characterised by a variable clinical phenotyp...

Omnitrope is a biosimilar growth hormone (GH) preparation with a lower acquisition cost than other GH preparations. We switched adult patients with growth hormone deficiency treated with Genotropin (n=14, age 59.2±13.7 [mean±SD] yrs, 8 male) to Omnitrope at an equivalent dose. There followed titration visits every month for 3 months then visits every 3 months until 9 months. GH dose (0.5±0.0 vs 0.5±0.0 mg [mean±SD],...

A 33-year-old lady presented to the surgeons with history of abdominal pain. CT scan abdomen done revealed massive adrenal enlargements reported as adrenal myelolipomas (left gland measuring 8.0×10.9×11.8 cm and multifocal lesions on the right with the larger one measuring 5.2×4.3×3.6 cm). She was referred to the endocrinology team where further history was elicited. She had been diagnosed as a child to have congenital adrenal hyperplasia (CAH) but was lost...

Background: Measurements of thyrotropin (TSH), free thyroxine (FT4) and triiodothyronine (FT3) are widely used diagnostic methods for thyroid function evaluation. However, some serum samples will demonstrate a nonspecific binding with assay reagents that can interfere with the measurement of these hormones. Few case reports of TSH interfering antibodies have described the presence of such interferences resulting in reported abnormal concentrations of thyroid hormones. Unusual ...

Background: Postural hypotension has been commonly described in elderly. Common causes include medication, fluid loss, adrenal insufficiency and autonomic dysfunction. Hyponatremia is not a disease in itself, but a manifestation of a variety of disorders and side-effects of diuretics; alternatively, it may be the only manifestation of certain disorders. We present a case of primary hypothyroidism presenting as collapse with postural hypotension and severe hyponatremia.<p c...

Background: Sunitinib is a tyrosine kinase inhibitor used in the treatment of metastatic GIST and renal cell carcinoma. Tyrosine kinase receptors are involved in tumour growth, angiogenesis and metastatic invasion. It can cause hypothyroidism but few cases have actually been reported. Mechanisms suggested for the incidence of hypothyroidism include antithyroperoxidase activity,1 and blocking uptake of iodine in the thyroid gland,2 or it may induce destruc...

Background: Thyroid fine needle aspiration cytology (FNAC) is an essential component of investigating discrete thyroid nodules. Grade THY3 Cytology implies a follicular lesion and usually requires diagnostic Hemithyroidectomy. Published data from UK suggests an incidence of malignancy in the range of 25 to 28% following Thy3 cytology. Nodular size of > 40 mm is shown to be significantly associated with increased incidence of thyroid malignancy. Aim: To assess the biochemic...

Back ground: Pituitary adenomas are the most common cause of a mass in the sella, accounting for up to 10–15% of intracranial neoplasm’s1. However, when dealing with abnormal intrasellar masses, a number of different etiologies are possible: germ cell tumour, metastatic tumours, granulomatous, and inflammatory processes2. We report an unusual case of primary pituitary lymphoma diagnosed on biopsy presenting as panhypopituitarism and Diabetes Ins...